Quantitative assessment of dosimetric parameters of the radiation treatment plan for unplanned changes in the fractionation scheme

Changes in the fractionation scheme of radiotherapy course have an impact on results treatment cancer patients. If changes are not taken into account, this leads to under-irradiation tumor cells and a possible occurrence subsequent relapses. There radiobiological models order take account errors radiation dose delivered tumor. They allow predicting control, as well toxicity level normal tissues after traditional RT.The objective work is assess effectiveness absorbed event, if RT changes, develop algorithm that takes breaks between sessions.In study, due change total time assessed analytically, graphical dependence efficiency duration unplanned interruption patients built for most common oncological localizations, procedures taking deviations from standard pattern developed.